MersV1, Main, Exploration, bibRecord, 002190

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

Identifieur interne : 002190 ( Main/Exploration ); précédent : 002189; suivant : 002191

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

Source :

Lancet. Infectious diseases : (print) [ 1473-3099 ] ; 2013.

RBID : Pascal:13-0311868

Descripteurs français

Pascal (Inist)
- Epidémiologie, Symptomatologie, Moyen Orient, Coronavirus, Pathologie de l'appareil respiratoire, Arabie saoudite, Exploration virologique, Homme, Syndrome respiratoire du Moyen-Orient.
Wicri :
- geographic : Arabie saoudite.
- topic : Homme.

English descriptors

KwdEn :
- Coronavirus, Epidemiology, Human, Middle East respiratory syndrome, Middle east, Respiratory disease, Saudi Arabia, Symptomatology, Virological exploration.

Abstract

Background Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). Clinical data on MERS-CoV infections are scarce. We report epidemiological, demographic, clinical, and laboratory characteristics of 47 cases of MERS-CoV infections, identify knowledge gaps, and define research priorities. Methods We abstracted and analysed epidemiological, demographic, clinical, and laboratory data from confirmed cases of sporadic, household, community, and health-care-associated MERS-CoV infections reported from Saudi Arabia between Sept 1, 2012, and June 15, 2013. Cases were confirmed as having MERS-CoV by real-time RT-PCR. Findings 47 individuals (46 adults, one child) with laboratory-confirmed MERS-CoV disease were identified; 36 (77%) were male (male:female ratio 3.3:1). 28 patients died, a 60% case-fatality rate. The case-fatality rate rose with increasing age. Only two of the 47 cases were previously healthy; most patients (45 [96%]) had underlying comorbid medical disorders, including diabetes (32 [68%]), hypertension (16 [34%]), chronic cardiac disease (13 [28%]), and chronic renal disease (23 [49%]). Common symptoms at presentation were fever (46 [98%]), fever with chills or rigors (41 [87%]), cough (39 [83%]), shortness of breath (34 [72%]), and myalgia (15 [32%]). Gastrointestinal symptoms were also frequent, including diarrhoea (12 [26%]), vomiting (ten [21%]), and abdominal pain (eight [17%]). All patients had abnormal findings on chest radiography, ranging from subtle to extensive unilateral and bilateral abnormalities. Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia (16 [34%]). Interpretation Disease caused by MERS-CoV presents with a wide range of clinical manifestations and is associated with substantial mortality in admitted patients who have medical comorbidities. Major gaps in our knowledge of the epidemiology, community prevalence, and clinical spectrum of infection and disease need urgent definition.

Affiliations:

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Le document en format XML

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<author><name sortKey="Flemban, Hesham" sort="Flemban, Hesham" uniqKey="Flemban H" first="Hesham" last="Flemban">Hesham Flemban</name>
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<author><name sortKey="Al Nassir, Wafa N" sort="Al Nassir, Wafa N" uniqKey="Al Nassir W" first="Wafa N." last="Al-Nassir">Wafa N. Al-Nassir</name>
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<author><name sortKey="Al Hakeem, Rafat F" sort="Al Hakeem, Rafat F" uniqKey="Al Hakeem R" first="Rafat F." last="Al-Hakeem">Rafat F. Al-Hakeem</name>
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<s2>Riyadh</s2>
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<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
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<s2>Riyadh</s2>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study</title>
<author><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
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<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
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<author><name sortKey="Al Rabeeah, Abdullah A" sort="Al Rabeeah, Abdullah A" uniqKey="Al Rabeeah A" first="Abdullah A." last="Al-Rabeeah">Abdullah A. Al-Rabeeah</name>
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<author><name sortKey="Al Rabiah, Fahad A" sort="Al Rabiah, Fahad A" uniqKey="Al Rabiah F" first="Fahad A." last="Al-Rabiah">Fahad A. Al-Rabiah</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>King Faisal Specialist Hospital</s1>
<s2>Riyadh</s2>
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<author><name sortKey="Al Hajjar, Sami" sort="Al Hajjar, Sami" uniqKey="Al Hajjar S" first="Sami" last="Al-Hajjar">Sami Al-Hajjar</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>King Faisal Specialist Hospital</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>4 aut.</sZ>
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<author><name sortKey="Al Barrak, Ali" sort="Al Barrak, Ali" uniqKey="Al Barrak A" first="Ali" last="Al-Barrak">Ali Al-Barrak</name>
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<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Arabie saoudite</country>
<wicri:noRegion>Prince Sultan Military Medical City</wicri:noRegion>
</affiliation>
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<author><name sortKey="Flemban, Hesham" sort="Flemban, Hesham" uniqKey="Flemban H" first="Hesham" last="Flemban">Hesham Flemban</name>
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<s2>Riyadh</s2>
<s3>SAU</s3>
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<country>Arabie saoudite</country>
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<author><name sortKey="Al Nassir, Wafa N" sort="Al Nassir, Wafa N" uniqKey="Al Nassir W" first="Wafa N." last="Al-Nassir">Wafa N. Al-Nassir</name>
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</affiliation>
</author>
<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>King Abdulaziz Medical City</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
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<author><name sortKey="Al Hakeem, Rafat F" sort="Al Hakeem, Rafat F" uniqKey="Al Hakeem R" first="Rafat F." last="Al-Hakeem">Rafat F. Al-Hakeem</name>
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<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>10 aut.</sZ>
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<author><name sortKey="Makhdoom, Hatem Q" sort="Makhdoom, Hatem Q" uniqKey="Makhdoom H" first="Hatem Q." last="Makhdoom">Hatem Q. Makhdoom</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Jeddah Regional Laboratory, Ministry of Health</s1>
<s2>Jeddah</s2>
<s3>SAU</s3>
<sZ>11 aut.</sZ>
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<country>Arabie saoudite</country>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zumla, Alimuddin I" sort="Zumla, Alimuddin I" uniqKey="Zumla A" first="Alimuddin I." last="Zumla">Alimuddin I. Zumla</name>
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<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Arabie saoudite</country>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Division of Infection and Immunity, University College London, and University College London Hospitals NHS Foundation Trust</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Global Centre for Mass Gatherings Medicine, Ministry of Health</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Arabie saoudite</country>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Public Health Directorate, Ministry of Health, and Al-Faisal University</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Arabie saoudite</country>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet. Infectious diseases : (print)</title>
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<imprint><date when="2013">2013</date>
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</sourceDesc>
<seriesStmt><title level="j" type="main">Lancet. Infectious diseases : (print)</title>
<title level="j" type="abbreviated">Lancet. Infect.  dis. : (print)</title>
<idno type="ISSN">1473-3099</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Epidemiology</term>
<term>Human</term>
<term>Middle East respiratory syndrome</term>
<term>Middle east</term>
<term>Respiratory disease</term>
<term>Saudi Arabia</term>
<term>Symptomatology</term>
<term>Virological exploration</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Epidémiologie</term>
<term>Symptomatologie</term>
<term>Moyen Orient</term>
<term>Coronavirus</term>
<term>Pathologie de l'appareil respiratoire</term>
<term>Arabie saoudite</term>
<term>Exploration virologique</term>
<term>Homme</term>
<term>Syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). Clinical data on MERS-CoV infections are scarce. We report epidemiological, demographic, clinical, and laboratory characteristics of 47 cases of MERS-CoV infections, identify knowledge gaps, and define research priorities. Methods We abstracted and analysed epidemiological, demographic, clinical, and laboratory data from confirmed cases of sporadic, household, community, and health-care-associated MERS-CoV infections reported from Saudi Arabia between Sept 1, 2012, and June 15, 2013. Cases were confirmed as having MERS-CoV by real-time RT-PCR. Findings 47 individuals (46 adults, one child) with laboratory-confirmed MERS-CoV disease were identified; 36 (77%) were male (male:female ratio 3.3:1). 28 patients died, a 60% case-fatality rate. The case-fatality rate rose with increasing age. Only two of the 47 cases were previously healthy; most patients (45 [96%]) had underlying comorbid medical disorders, including diabetes (32 [68%]), hypertension (16 [34%]), chronic cardiac disease (13 [28%]), and chronic renal disease (23 [49%]). Common symptoms at presentation were fever (46 [98%]), fever with chills or rigors (41 [87%]), cough (39 [83%]), shortness of breath (34 [72%]), and myalgia (15 [32%]). Gastrointestinal symptoms were also frequent, including diarrhoea (12 [26%]), vomiting (ten [21%]), and abdominal pain (eight [17%]). All patients had abnormal findings on chest radiography, ranging from subtle to extensive unilateral and bilateral abnormalities. Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia (16 [34%]). Interpretation Disease caused by MERS-CoV presents with a wide range of clinical manifestations and is associated with substantial mortality in admitted patients who have medical comorbidities. Major gaps in our knowledge of the epidemiology, community prevalence, and clinical spectrum of infection and disease need urgent definition.</div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>University College de Londres</li>
</orgName>
</list>
<tree><country name="Arabie saoudite"><noRegion><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
</noRegion>
<name sortKey="Al Barrak, Ali" sort="Al Barrak, Ali" uniqKey="Al Barrak A" first="Ali" last="Al-Barrak">Ali Al-Barrak</name>
<name sortKey="Al Hajjar, Sami" sort="Al Hajjar, Sami" uniqKey="Al Hajjar S" first="Sami" last="Al-Hajjar">Sami Al-Hajjar</name>
<name sortKey="Al Hakeem, Rafat F" sort="Al Hakeem, Rafat F" uniqKey="Al Hakeem R" first="Rafat F." last="Al-Hakeem">Rafat F. Al-Hakeem</name>
<name sortKey="Al Hakeem, Rafat F" sort="Al Hakeem, Rafat F" uniqKey="Al Hakeem R" first="Rafat F." last="Al-Hakeem">Rafat F. Al-Hakeem</name>
<name sortKey="Al Nassir, Wafa N" sort="Al Nassir, Wafa N" uniqKey="Al Nassir W" first="Wafa N." last="Al-Nassir">Wafa N. Al-Nassir</name>
<name sortKey="Al Rabeeah, Abdullah A" sort="Al Rabeeah, Abdullah A" uniqKey="Al Rabeeah A" first="Abdullah A." last="Al-Rabeeah">Abdullah A. Al-Rabeeah</name>
<name sortKey="Al Rabiah, Fahad A" sort="Al Rabiah, Fahad A" uniqKey="Al Rabiah F" first="Fahad A." last="Al-Rabiah">Fahad A. Al-Rabiah</name>
<name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
<name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name>
<name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<name sortKey="Flemban, Hesham" sort="Flemban, Hesham" uniqKey="Flemban H" first="Hesham" last="Flemban">Hesham Flemban</name>
<name sortKey="Makhdoom, Hatem Q" sort="Makhdoom, Hatem Q" uniqKey="Makhdoom H" first="Hatem Q." last="Makhdoom">Hatem Q. Makhdoom</name>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<name sortKey="Zumla, Alimuddin I" sort="Zumla, Alimuddin I" uniqKey="Zumla A" first="Alimuddin I." last="Zumla">Alimuddin I. Zumla</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zumla, Alimuddin I" sort="Zumla, Alimuddin I" uniqKey="Zumla A" first="Alimuddin I." last="Zumla">Alimuddin I. Zumla</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

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